Tuesday, August 25, 2020
Working Capital Managment Free Essays
The board Of Working Capital Introduction Working Capital-Definition Working Capital is the money expected to pay for the everyday activity of the business. Alongside long haul ventures , business likewise needs assets for transient purposes to back current activities. Interest in transient resources like money, inventories, indebted individuals and so forth. We will compose a custom exposition test on Working Capital Managment or then again any comparative point just for you Request Now , is called ââ¬ËShort-term Fundsââ¬â¢ or ââ¬ËWorking Capitalââ¬â¢. Subsequently, the administration of Working Capital is significant for the smooth running of business. Calcution of Working Capital Working Capital of an organization is the contrast between the Current Assets and the Current Liabilities of the organization. Working capital=Current Assets-Current Liabilities Current Assets: Assets of the business held as cash(e. g money at the bank) or that can be immediately transformed into money. Current Assests Stocks Cash Debtors Investments Current Liabilities: Money owed by a business association which is to be paid inside next a year Current Liabilities Trade Creditors Dividends Tax collection Short term credits Circulating capital â⬠working capital is otherwise called coursing capital or current capital. ââ¬â¢ ââ¬Å"The utilization of the term circling capital as opposed to working capital shows that its stream is round in nature. â⬠Structure of Working Capital The various components or segments of current resources and current liabilities comprise the structure of working capital which can be represented looking like an outline as follows: Working Capital Cycle clarifies that the measure of money is acquired for the most part from issue of offers, getting and activities. Money reserves are utilized to buy fixed resources, crude materials and used to pay to loan bosses. The crude materials are prepared; wages and overhead costs are paid which in result produce completed products available to be purchased. Working Capital dissemination resembles the blood course in the human body as once it stops the entire business gets dead. Grouping of Working Capital Working Capital can be arranged in different manners. Applied characterization â⬠There are two idea of working capital viz. , quantitative and subjective. The quantitative idea considers as the present resources while the subjective idea considers the overabundance of current resources over current liabilities. Deficiency of working capital exists where the measure of current liabilities surpasses the measure of current resources. The above can be summed up as follows: (I) Gross Working Capital = Total Current Assets (ii) Net Working Capital = Excess of Current Assets over Current Liabilities (iii) Working Capital Deficit = Excess of Current Liabilities over Current Assets. Arrangement based on money related reports â⬠The nformation of working capital can be gathered from Balance Sheet or Profit and Loss Account; as such the working capital might be named follows: (I) Cash Working Capitalâ⬠This is determined from the data contained in benefit and misfortune account. This idea of working capital has expected an incredible hugeness as of late as it shows the sufficiency of income in business. It depends on ââ¬ËOperating Cycle Conceptââ¬â¢s (ii) Balance Sheet Working Capitalâ⬠The information for Balance Sheet Working Capital is gathered from the monetary record. On this premise the Working Capital can likewise be partitioned in three additional sorts, viz. net Working Capital, net Working Capital and Working Capital shortfall. Arrangement on the Basis of Variability â⬠Gross Working Capital can be separated in two classifications viz. ,(I) changeless or fixed working capital, and (ii) Temporary, Seasonal or variable working capital. Such sort of arrangement is significant for supporting choices. (I) Temporary Working Capital â⬠Temporary Working Capital is additionally called as fluctuating or occasional working capital. This speaks to extra speculation required during flourishing A good seasons. It increments with the development of the business. Brief working capital is the extra resources required to meet the varieties in deals over the changeless level. â⬠This can be determined as f ollows: Temporary Working Capital = Total Current Assets â⬠perpetual Current Assets (ii) Permanent Working Capital â⬠It is a piece of complete current resources which isn't changed because of variety in deals. There is consistently a base degree of money, inventories, and records receivables which is constantly kept up in the business regardless of whether deals are diminished to a base. Measure of such venture is called as perpetual working capital. Changeless Working Capital is the measure of working capital that endures after some time paying little heed to vacillations in deals. â⬠This is likewise called as normal working capital. Significance of Working Capital Management For smooth running a venture, sufficient measure of working capital is basic. Productivity around there can help, to use fixed resources profitably, to guarantee the firmââ¬â¢s long haul achievement and to accomplish the general objective of boost of the investors, subsidize. Deficiency or awf ul administration of money may bring about loss of money rebate and loss of notoriety due to non-installment of commitment on due dates. Deficient inventories might be the primary driver of creation held up and it might urge the undertakings to buy crude materials at ominous rates. Like-wise office of credit deal is likewise basic for deals advancements. It is properly seen that ââ¬Å"many multiple times business disappointment happens because of absence of working capital. Satisfactory working capital gives a pad to awful days, a worry can pass its time of discouragement absent a lot of trouble. The hugeness of sufficient working capital is ââ¬Å"to stay away from break in the creation plan and look after deals, a worry equires assets to fund inventories and receivables. â⬠The ampleness of money and current resources along with their effective taking care of essentially decides the endurance or death of a worry. An endeavor ought to keep up satisfactory working capital for its smooth working. Both, over the top working capital and lacking working capital will weaken the gainfulness and general strength of a w orry. The risk of inordinate working capital are as per the following: Heavy interest in fixed resources ââ¬A concern may put vigorously in its fixed resources which isn't advocated by real deals. This may make circumstance of over capitalization. Careless acquisition of materials-Inventory is bought wildly which brings about lethargic moderate moving and out of date stock. Simultaneously it might expand the expense due to misusing, squander, robbery, and so forth. Theoretical propensities â⬠Speculative inclinations may increment and if benefit is expanded profit dispersion will likewise increment. This will hamper the picture of a worry in future when theoretical misfortune may begin. Liberal credit â⬠Due to liberal credit, size of records receivables will likewise increment. Liberal credit office can build awful obligations and wrong practices will begin, in regards to postpone in installments. Recklessness â⬠Excessive working capital will prompt lack of regard about costs which will antagonistically influence the productivity. Scarcity of working industrialist likewise awful and has the accompanying threats: 1. Execution of working plans becomes troublesome and a worry may not accomplish its benefit target. 2. It is hard to deliver profit because of absence of assets. 3. Haggling limit is decreased in credit buys and money markdown couldn't be benefited. 4. An undertaking looses its notoriety when it gets troublesome even to meet everyday duties. 5. Working wasteful aspects may sneak in when a worry can't meet it money related guarantees. 6. Deteriorates development as the assets are not accessible for new tasks. 7. A worry should acquire assets at an over the top pace of enthusiasm for instance of need. 8. At times, a worry might be bound to deal its item at a decreased rates to gather subsidizes which may hurt its picture. Which means of Working Capital Management The administration of current resources, current liabilities and between connection between them is named as working capital administration. Working capital administration is worried about issues that emerge in endeavoring to deal with the present resources, the present liabilities and the between relationship that exist between them. â⬠practically speaking, ââ¬Å"There is normally a differentiation settled on between the venture choices concerning current resources a nd the financing of working capital. â⬠From the abovementioned, the accompanying two parts of working capital administration develops: (1) To decide the size of current resources or ââ¬Å"level of working capitalâ⬠and (2) To decide the method of financing or ââ¬Å"hedging choices. Essentialness of Working Capital Management Funds are required in each business for carrying on everyday tasks. Working capital assets are viewed as the existence blood of a business firm. A firm can exist and get by without making benefit however can't make due without working capital assets. In the event that a firm isn't procuring benefit it might be named as ââ¬Ësickââ¬â¢, however, not having working capital may cause its chapter 11 working capital so as to endure. The choices are not lovely. Insolvency is one other option. Being obtained on horrible term as another. In this manner, each firm should conclude how to adjust the measure of functioning capital it holds, against the danger of disappointment. â⬠Working capital has obtained an incredible essentialness and sound situation in the ongoing past for the twin objects of benefit and liquidity. In time of rising capital expenses and alarm reserves, the working capital is one of the most significant zones requiring the executives audit. It is appropriately seen that, ââ¬Å"Constant manageme
Saturday, August 22, 2020
Cloning - Stronger, Smarter, and More Perfect Humans :: Cloning Argumentative Persuasive Argument
Cloning - Stronger, Smarter, and More Perfect Humans A couple of years prior if you somehow happened to get some information about the potential outcomes of cloning they would in all probability state it was unimaginable. This disposition towards cloning has been held into conviction as of not long ago when researchers in Scotland cloned a sheep. Also, following researchers in Oregon cloned a monkey (Fackelmann 276). The most significant achievements of the century in science has happened and we are not prepared for it. The logical achievement of cloning has caused a lot of contention in the media and furthermore in the legislature. The focal points of cloning are huge to humankind and can't be disregarded. I accept that cloning people is the thing that humankind needs to progress. People would be more grounded, more intelligent, and progressively great. Researchers could expel awful qualities from the guardians and supplant it with a decent one. In the event that one of the guardians had a terrible quality or inherited sickness this could be expelled from the incipient organism and supplanted with another perfect quality. This procedure is called undeveloped organism screening it is utilized to decide whether the youngster has gotten the faulty quality. A few undeveloped organisms could be cloned, at that point the DNA from one of the incipient organisms would then be evacuated and standard hereditary testing would be utilized to identify whether that undeveloped organism contained the hereditary illness. In the event that this cloned embryo containd a sickness at that point one of different incipient organisms could be utilized for implantation in a parent, this ensures that the youngster would be liberated from hereditary infection (Marshall 1025). For the individuals who can't help contradicting cloning I am certain if there kid could be spared from a hereditary ailment they would reevaluate cloning. Imagine on the off chance that one of your companions or relatives needed a liver or on the other hand kidney. In all probability you would give your own liver or kidney to spare there life. Be that as it may, at that point you are one organ short. Well this happens a great deal and appears to work fine. Be that as it may, on the off chance that they required another heart you may experience difficulty discovering one. Not on the off chance that you had a clone of yourself that could flexibly you with another organ or perhaps a family members organ that was normally more grounded (Cloning 1117). Somebody could supplant their old organs with new ones and broaden their life expectancy. Thousands of lives that could be spared on the off chance that we had the innovation and progressed study of cloning accessible. In any event, tolerating an organ from a relative it might fizzle, it must be good with our body framework , on the off chance that its your clone, at that point its
Tuesday, July 28, 2020
A Morning With Sir Tim Berners-Lee
A Morning With Sir Tim Berners-Lee This morning I attended a lecture in Stata, given by Sir Tim Berners-Lee, the guy who invented the world wide web. (That sentence alone is pretty awesome. But I digress.) Tim was pretty fascinating, so I checked out his site to learn more about him. My favortite page is the one on which he answers questions for kids. I particularly like his answer to the last question. It was a bit weird to be sitting in the same room with the guy who was responsible for changing the world so significantly. Think about it what would the last ten years have been like without the web? And yet in person hes just a guy. Not the guy who revolutionized everything from commerce to politics to college admissions with his invention. No, in person hes just a nice, friendly guy with talents in physics and computers who cared deeply about facilitating communication within human civilization, so he did something about it. I dont think it was ever his plan to change the world. That part was just icing on the cake. As he explains on the kids page: Think about most of the bad things that have happened between people in your life. Maybe most of them come down to one person not understanding another. Even wars. Lets use the Web to help people understand each other. Sometimes I think the best ideas in the world begin as the most simple ones. Lets communicate. Bravo, Sir Tim.
Friday, May 22, 2020
Easy Projects .NET - Free Essay Example
Sample details Pages: 7 Words: 2161 Downloads: 9 Date added: 2017/06/26 Category IT Essay Type Narrative essay Did you like this example? There are many kinds of Software tools to harness the potential, project managers need to take the next step beyond the development of the project and project managers most now focus on the project management software tools. Each software tool has strengths and weaknesses upon the requirements and project developments. The undertaken passages will describe the some project management software tools features. Donââ¬â¢t waste time! Our writers will create an original "Easy Projects .NET" essay for you Create order Easy Projects .NET is a project collaboration software system that was specifically designed to make web-based project management, task tracking and team collaboration hassle free and straightforward. The easiest all-in-one web based project management software. Whether you are a marketing department or an IT department, or whether you are an administrative assistant or a project manager, or perhaps your business is designing furniture or designing software Easy Projects .NET will make your life easier! This directory of Project Management Software will assist you in finding the project management solution that is right for your situation. The directory includes: project management software, bug and defect tracking, project accounting, project estimating, project portfolio management, project scheduling, requirements management, and resource planning and scheduling software. Microsoft Project plans to share with your colleagues online simply login and import. Anyone in y our team can login from anywhere in the world at any time, to see their tasks and enter their progress to date. And you can see the current status real-time, at every minute of the day. This helps keep your projects on track. Like Microsoft Project, ProjectManager.com allows you to create task lists, assign resources and dependencies. But unlike Microsoft Project, you can view your Actual, Planned and Baseline progress all at the same time. You can also view the project status on your very own customized Project Dashboard and when your team fill-in timesheets, expenses, risks, changes and issues the dashboard automatically updates, giving you the status of your project real-time. One of the limitations of MS Project is that its installed on the desktop, so its difficult for your team to collaborate on a single project plan. You constantly need to be sending each other project files to load, making the process slow and error prone. But using this new innovative software, you c an import your MS Project plans just once and everyone in your team can view it online. You can then set the security levels, so each user can view / edit the plans based on your personal preferences. This way, you can all work on the same plans at the same time. Its quick and simple to import your MS Project plans and start collaborating today. Strengths of Microsoft Project plans This innovative software includes all of the commonly used features that MS Project has to offer, and more so why buy MS Project? It saves you the expensive up front licensing costs and it offers you the collaboration features you need to succeed. Project management software is a term covering many types of software, including scheduling, cost control and budget management, resource allocation, collaboration software, communication, quality management and documentation or administration systems, which are used to deal with the complexity of large projects. 1 Tasks or activities of project management software 1.1 Scheduling One of the most common tasks is to schedule a series of events, and the complexity of this task can vary considerably depending on how the tool is used. Some common challenges include: â⬠¢ Events which depend on one another in different ways or dependencies â⬠¢ Scheduling people to work on, and resources required by, the various tasks commonly termed resource scheduling â⬠¢ Dealing with uncertainties in the estimates of the duration of each task â⬠¢ Arranging tasks to meet various deadlines â⬠¢ Juggling multiple projects simultaneously to meet a variety of requirements 1.2 Calculating critical path In many complex schedules, there will be a critical path, or series of events that depend on each other, and whose durations directly determine the length of the whole project (see also critical chain). Some software applications (for example, Dependency Structure Matrix solutions) can highlight these tasks, which are often a good candidate for any optimization effort. 1.3 Providing information Project planning software needs to provide a lot of information to various people, to justify the time spent using it. Typical requirements might include: â⬠¢ Tasks lists for people, and allocation schedules for resources â⬠¢ Overview information on how long tasks will take to complete â⬠¢ Early warning of any risks to the project â⬠¢ Information on workload, for planning holidays â⬠¢ Evidence â⬠¢ Historical information on how projects have progressed, and in particular, how actual and planned performance are related â⬠¢ Optimum utilization of available resource 2. Approaches to project management software 2.1 Desktop Project management software can be implemented as a program that runs on the desktop of each user. This typically gives the most responsive and graphically-intense style of interface. Desktop applications typically store their data in a file, although some have the ability to collaborate with other users (see below), or to store their data in a central database. Even a file-based project plan can be shared between users if its on a networked drive and only one user accesses it at a time. Desktop applications can be written to run in a heterogeneous environment of multiple operating systems, although its unusual. 2.2 Web-based Project management software can be implemented as a Web application, accessed through an intranet or extranet using a web browser. This has all the usual advantages and disadvantages of web applications: â⬠¢ Can be accessed from any type of computer without installing software â⬠¢ Ease of access-control â⬠¢ Naturally multi-user â⬠¢ Only one software version and installation to maintain â⬠¢ Typically slower to respond than desktop applications â⬠¢ Project information not available when the user (or server) is offline. â⬠¢ Some packages do allow the user to go-offline 2.3 Personal A personal project management application is one used at home, typically to manage lifestyle or home projects. There is considerable overlap with single user systems, although personal project management software typically involves simpler interfaces. See also non-specialised tools below. 2.4 Single user A single-user system is programmed with the assumption that only one person will ever need to edit the project plan at once. This may be used in small companies, or ones where only a few people are involved in top-down project planning. Desktop applications generally fall into this category. 2.5 Collaborative A collaborative system is designed to support multiple users modifying different sections of the plan at once, for example, updating the areas they personally are responsible for such that those estimates get integrated into the overall plan. Web-based tools, including extranets, generally fall into this category, but have the limitation that they can only be used when the user has live Internet access. Some tools allow team members to check out their schedules (and others as read only) to work on them while not on the network. When reconnecting to the database, any changes are synchronized with the other schedules. 2.6 Integrated An integrated system combines project management or project planning, with many other aspects of company life. For example, projects can have bug tracking issues assigned to each project, the list of project customers becomes a customer relationship management module, and each person on the project plan has their own task lists, calendars, and messaging functionality associated with their projects. Microsoft Project Standard 2003 Trial software enables you to evaluate the product on your system before making a purchase decision. Trial versions contain all Microsoft Project features, but can only be used for a limited time. Microsoft Office Compatibility: â⬠¢ Microsoft Office interface Navigate intuitively with the familiar Office interface. â⬠¢ Excel and Outlook Import Easily import and leverage data from Microsoft Excel and Microsoft Outlook to start a Microsoft Project plan. â⬠¢ Smart Tags Get automatic, contextual suggestions alerting you of alternative scheduling options. â⬠¢ Presentation Wizard Transfer project data smoothly to Microsoft PowerPoint, Microsoft Word, or Microsoft Visio. â⬠¢ Add-In for Visio diagramming Create a Work Breakdown Structure (WBS) chart in Visio from Project 2003 data. â⬠¢ Built-in online help Use Office Online to get training, templates, and more. Planning and Tracking Tools: â⬠¢ Gantt Charts, Calendars, Network Diagrams, and Task Sheets Present project data in versatile views. â⬠¢ Additional project templates Jump-start common projects and promote consistency. â⬠¢ Interactive, Step-By-Step Planning Aide Set up and manage projects effectively with the Project Guide. â⬠¢ Multiple Baselines Track status over project life cycle with 11 full baselines. â⬠¢ Add-In for comparing project files Compare two versions of the same project and report the results. Reporting and Information Sharing: â⬠¢ Printing Wizard Easily format and print concise project plans. â⬠¢ XML Reporting Wizard Generate an Extensible Markup Language (XML) file from project data to create custom reports. â⬠¢ Project information sharing Share project-related documents using a Microsoft Windows SharePoint Services workspace (Requires Microsoft Windows Server 2003). Resource Management: â⬠¢ Resource availability graphs Evaluate resource workload and availability, and resolve over-allocations. â⬠¢ Resource information import Import resource information from Microsoft Active Directory or a Microsoft Exchange address book. VPMi Professional includes everything VPMi Express has PLUS everything your organization needs to achieve better team, customer, and partner collaboration including: 1. Service requests (Idea creation) 2. Project management software 3. Earned value management 4. Microsoft Project integration 5. Enterprise Project Management Workflow 6. Post project assessments/scoring 7. Resource management software 8. Program management 9. Portfolio management 10. IT Project management (Support) With VPMi Professional web-based project management you can start for free today No minimum number of users: No large capital expenses for software or servers. Free to try for 30 days and unlimited users. Cancel at any time. Lowest competitive cost for full PPM: Start a pilot for only $30/month (first month is FREE). Add as few or as many employees, suppliers, and customers every month with no commitments. Download your data at any time. Cancel at any time. Only pay for people that use the system that month: Low monthly costs (less then 1/2 of next nearest competitor). Average end user only pays $10/month. Many users do not even need paid accounts: Only pay month to month for those that need to use the system. Lower customer service and management costs: Reports download to Excel, Word, and MS Project for easy emailing. No servers to purchase and setup: One stop shop for all project status, reporting, and billing information. No software footprint or compatibility/upgrade fees: Eliminates IT project management servers, software management, procurement, setup, maintenance, and energy costs. No dedicated technical support needed on-site: VPMi Pro is a web-based project management solution so there are no desktop costs. Working with tools you own know saves training, startup time, and money: Software service is web-based and supported remotely as part of the low user cost. Eliminate expensive redundant systems: Integration with Microsoft Project insures quick transition from existing plans to VPMi. Security is extraordinary and requires no further investment: Consolidate and eliminate expensive IT project management, timesheet, help desk, resource management software, and other tracking systems. Eliminate wasteful meetings: VPMi Pro online project management uses banking standards for secure communications. Guaranteed service levels (5 9s) insure users have access to their work. One online project management source of reporting and projects saves teams time and the company money: Eliminate needless meetings with online collaboration and status reporting. Resource management software shows who has availability without making phone calls and guessing. Improve customer loyalty through project portal and collaboration for more follow on engagements: Manage more projects with the same number of people. Resource management software shows Supply vs. Demand of resources over time to see who has excess capacity and who is overbooked. Cancel and Fast Track projects quickly: Enter issues and feedback 24/7 with VPMis online project management capabilities. Automatic mail updates to teams eliminate confusion and project administration. Customers can also enter change requests and new service requests for improved opportunity capture/delivery. Meet goals while lowering staff levels: Projects at risk or in fact going over their allotted budgets and timelines can be quickly put on hold or canceled while high business value projects with the best returns can be prioritized and optimized. Resource management software shows you if you have the resources to execute on your portfolios. Filter, download, and port into existing systems: Going through mandatory budget and staff cuts? VPMi has demonstrated improve efficiency and project accountability with less staff. Supply and Demand resource management software shows how many people (by role) you need to meet your demand. What-if allows you to eliminate functions and people under/not utilized. No capitalized purchase expense : Data screens allow sophisticated filtering and all download into MS Word and MS Excel for porting into new/old systems. Our resource management software reports integrate with email and MS Excel. Save money when auditing projects: Since the VPMi Pro is a web based project management solution there is no need to capitalize the expense (software as a service). Teams can utilize best practices without spending money building their own processes : Projects are easily audited with included project management tools. Customers save time and money in compliance functions like Sarbanes Oxley. Included project management tools utilize Project Management Institute (PMI ) PMBOK best practices for easy recognition of forms and terminology to project teams.
Saturday, May 9, 2020
Qualitative Critique A Study - 1663 Words
Qualitative Critique The qualitative approach to research is anchored in the ideographic tradition and seeks to focus on the insiders world and the meanings that are attached to behaviour. While this is a general view of qualitative studies each qualitative design has unique foci. Hudacek (2008) examined the concept of caring in the work of nurses using a phenomenological design. Phenomenology gives attention to the subjective social reality. It gives value to the individual experience of the actor even within highly structured organizations. It is through the everyday experiences that meaning is constructed. The use of phenomenology is therefore highly consistent with the attempt to understand the meaning of caring. The design and the stated purpose of the researcher are highly congruent. The researcher noted that the purpose of the study was to describe the dimensions of caring. Phenomenology is useful for unearthing the individuals understanding of their own behavior and consequently the meaning they attach to particular actions. Another reason the design is in harmony with the purpose of the study is identified by the author; there is a lack of narratives of nursing care. The nursing profession has an acute absence of stories that in their collective strength describe not only what nurses do but why. The why component is a critical aspect of the nursing profession. It determines how actors understand their roles, and the behaviors that are consistent with thoseShow MoreRelatedQualitative Critique Of A Qualitative Study1207 Words à |à 5 Pages Qualitative Critique Paper: Critique of a Qualitative Study Grace Fahham Shenandoah University What was the purpose of the study? The purpose of this qualitative study was to describe how occupational therapistsââ¬â¢ involved client-centred activities in daily living (CADL) in their practice. 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The purpose of the research was to determine whether leg-crossing impacted the results of blood pressure measurements. The research conducted by Palese, SkrapRead MoreQualitative Research Article On Pressure Ulcers980 Words à |à 4 PagesQualitative Research Article Critique According to Stockhausen Conrick (2002), ââ¬Å"Learning how to critique research articles is one of the fundamental skills of scholarship in any disciplineâ⬠(p. 38). Burns Grove (2011) found ââ¬Å"An intellectual critical appraisal of a study involves a careful, complete examination of that study to judge its strengths, weaknesses, meaning, credibility, and significance for practiceâ⬠(p. 419). The extent, amount and nature of publications accessible today by differentRead MoreQualitative Research : Quantitative Research1442 Words à |à 6 Pageslevel, qualitative research involves an interpretive, naturalistic approach to the world. This means that qualitative researchers study things in their natural settings, attempting to make sense of, or interpret, phenomena in terms of the meanings people bring to them. (Denzin Lincoln, 2005, p. 3) Different from quantitative research that collects and analyzes numerical data, qualitative research deals with non-numerical data such as interviews, participant observations, audio and visual imagesRead MoreEssay on Research Critique Part 1659 Words à |à 3 Pages Research Critique Part 1 Grand Canyon University Introduction to Nursing Research NRS-433V Mary OConnell September 5, 2013 Research Critique Part 1 This paper will critique a qualitative research study published in the Journal of Medical Ethics in 2004, By Dr Helen Aveyard, about how nurses manage patients who refuse nursing care procedures. The article explains how nurses view informed consent as not being essential to nursing care procedures. Problem Statement The clinical problemRead MoreResearch Critique Part 1736 Words à |à 3 PagesResearch Critique Part 1 Jenna Franz Grand Canyon University Introduction to Nursing Research NRS-433V Mary OConnell September 5, 2013 Research Critique Part 1 This paper will critique a qualitative research study published in the Journal of Medical Ethics in 2004, By Dr Helen Aveyard, about how nurses manage patients who refuse nursing care procedures. The article explains how nurses view informed consent as not being essential to nursing care procedures. Problem Statement The clinicalRead MoreA Research Study On Sedation Management799 Words à |à 4 PagesResearch Critique The design of both quantitative and qualitative research offer valuable information to the health sciences. There are circumstances when certainty is necessary, and a quantitative design is needed. In contrast, there are times when an understanding of the quality of a particular social interaction is needed. The paper will apply a quantitative and a qualitative research article to the topic of sedation management to help validate meaning gleaned from two different research designsRead MoreDefinition, Consistency And Neutrality Must Be Addressed?976 Words à |à 4 Pagessystematic inquiry into human condition is executed. There are some critiques of qualitative research namely reliability/dependability, generalization/transferability, flexibility, time consuming, objectivity/confirmability, credibility/believability, and sampling/variables. The criticism of qualitative studies inability to generalize their findings to the population is not valid. Williams et al., (2004) asserts that the goal of qualitative research is that one of interpretation, describing individualsââ¬â¢Read MoreEssay on Qualitative Analysis Critique1343 Words à |à 6 PagesQualitative Research Critique There are many differences between quantitative and qualitative research. Such things like: quantitative research provides only variables that can predict specific results but it does not tell us very much about how the variables affect an individualââ¬â¢s life course. Qualitative research adversely provides an enriched understanding of characteristics, qualities, attributes, and environmental factors affecting life events. Qualitative analysis can give understanding
Wednesday, May 6, 2020
Greenhouse Effect Is the Result of Deforesting Free Essays
Can you imagine our world facing everyday hurricanes, tsunamis, earthquakes, climate change, extinction caused indirectly by human activities? Yes, you can because it is happening right now while you are staying here in the classroom. A few days ago, Japan has been devastating by a massive earthquake of 8. 9 magnitudes, followed by a powerful force of a tsunami. We will write a custom essay sample on Greenhouse Effect Is the Result of Deforesting or any similar topic only for you Order Now Some scientists will say that it is a natural disaster and we have nothing to do with it, other will say that human activities help to accelerate these natural phenomenons. Human footprint has left behind him not only a new era of technologyââ¬â¢s revolution, but also the destruction of nature. Today, environmental concern such as the growth of carbon emission in the atmosphere seems of high importance in global news. The greenhouse effect continues to increase rapidly and meanwhile accelerate global warming. In fact, your car, your house and even your air conditioning are used to produce energy and, meanwhile, used to enhance greenhouse effect. Indeed, human activities such as burning fossils fuels contribute to accelerate the natural phenomenon of greenhouse effect on Earth. More carbon dioxide in the air, more infrared rays are being trapped in the Earth and as a result temperature increased. Can you imagine living with a high temperature? Believe it or not, but this happened. In 2005, Las Vegas has almost reached 50oC, a temperature record in North America in 21st century. Although, many scientists believe that the Earth has always had natural disaster. Nonetheless, it is not a coincidence if the number of natural disaster increases while the number of human activities increases. We play a major role on the vulnerability of natural disaster. The whole world is interconnected. Climate change doesnââ¬â¢t just affect the atmosphere and the oceans but the earthââ¬â¢s crust as well. ââ¬â¢Ã¢â¬â¢ said Professor Bill McGuire of University College London. He also added that ââ¬Å"When the ice is lost, the earthââ¬â¢s crust bounces back up again and that triggers earthquakes, which trigger submarine landslides, which cause tsunamisâ⬠. Accordi ng to experts, human activities influence the equilibrium of nature. We must begin to consider the consequences of greenhouse effect. We must begin to preserve our nature. We must begin to stop deforesting. We must begin to see life in green. In every consciousness of human beings, we must find an ecological thinking. Men, women, children, human beings of this planet, we must begin to recognize the alarming situation of our environment and together work to solve it. For the sake of our lives and for future generation, it is time we stopped ignoring our responsibility on the environment. Today, we can change and this will certainly serve as a milestone in our environment. Thank you We must stop pointing others, and see that our three other fingers are pointing ourselves, because we are the one who can change things. How to cite Greenhouse Effect Is the Result of Deforesting, Papers
Tuesday, April 28, 2020
Philippines and Drama Western Drama free essay sample
Oriental Drama Western drama, the drama of Asia originated as an elaborntion of liturgical practices. Eastern drama, in general, is based on the concept of sangita or (sammita), the threefold art of music, dance, and poetry,fused into single artistic entity. *Asian actors long ago rejected realistic presentation in favor of obstruction and symbolism. *19th century western influences began to felt in the asian theater resulting not in the nature of an assimilation, but in a complete break with native tradistion. Philippine drama Duplo-was a poetical debate held by trained men and women in the ninth night, the last night of the heads of the game. Karagatan-was also a poetical debate like a duplo but its participants were amateurs. Both the duplo and karagatan were held in the homes the thene was all about a ring that fell into the sea. 1598-First recorded drama was staged in cebu. -it was commedia written by Vicente puche was performed in honor of msgr. We will write a custom essay sample on Philippines and Drama Western Drama or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Pedro de agurto. Cebuââ¬â¢s fisrt bishop. 609-another staged play for portraying the light of sta. barbara was staged in bicol. Three kinds of plays became popular among the masses during the spanish era 1. Cenakulo-very heavy drama shown in relation to the life sacrifices and death of jesus Christ. -month of april, depending the exact fate of holy week. Two kinds of presentation: 1. ablada(oral) 2. kantada(song) Version of cenakulo: Tagalog, Iluko, Kapampangan, Bikol and Bisayan version are some example. . Moro moro- cloak and dagger play depicting the wars between the Christians and the Muslims, with the Christians always on the winning side. Written by: Fr. Jeronimo Perez and was staged in Manila in 1637. 3. Zarsuela-musical comedy, melodrama with songs and dances- -wards love. Fear, grief, sorrow or any emotional reactions sublime. Junto Al Pasig(besides the pasig)- by rizal -staged at Ateneo De manila on December 8,1880.
Friday, March 20, 2020
Routines in Healthcare that seem to be inefficient Essays
Routines in Healthcare that seem to be inefficient Essays Routines in Healthcare that seem to be inefficient The scientific management theory was advanced by Frederick W. Taylor. He was an engineer and inventor. The theory seeks to enhance an organization's efficiency by systematically increasing the efficiency of task completion by using engineering, scientific, and mathematical analysis. Additionally, the aim is to reduce waste, upsurge the methods and production methods and generate a just distribution of goods. This purpose serves the employers, employees and societys common interests (America in Class, n.d.). He established 4 principles centered on this theory: 1. Managers ought to collect information, analyze it, and lessen it to laws, rules, or mathematical formulas. 2. Managers must scientifically choose and train workers. 3. Managers should guarantee that the techniques which are developed by science are utilized by the workers. 4. Managers are duty-bound to apply the work similarly between workers and themselves where they apply scientific management theories to the planning process and the workers carry out the tasks with regard to the plans. An instance of a routine in healthcare that appear to be inefficient can relate to understaffing a floor with a potentially high acuity rate. In the medical facility that I usually work in, conscription is grounded on the census of the floor as opposed to the level of acuity which ultimately leads to a culmination of shift overtime, thus in my view, this leads to nurse dissatisfaction as well as more medical errors. An instance of a participative decision making that is present at the workplace is inspiring leading to nurses becoming members of the hospitals Shared Governance Committee. Regularly, such a committee provides autonomy to nurses to be involved in the decision making process in their practice. Most hospital have nurses who are part of recruitment and retention council, nursing informatics council, nursing practice council, and MAGNET council as a component of the powerful Shared Governance Committee. References America in Class. (n.d.). Retrieved from http://americainclass.org/wp content/uploads/2013/03/Taylor-Scientific-Management-1910-excerpt.pdf
Tuesday, March 3, 2020
Varying Approaches for Principled Eclecticism for ESL
Varying Approaches for Principled Eclecticism for ESL A few years ago I was introduced to principled eclecticism as a means of establishing ESL/EFL class objectives. Basically, principled eclecticism refers to the use of various teaching styles in a discriminating manner as required by learner needs and styles. Applying Principled Eclectisim While this loose approach may sound either ideal or simplistic depending on your point of view, it requires a basic grasp of some of the principle schools of thought as a means of getting an overview of issues directly related to satisfying learners needs. In a nutshell, the application of principled eclecticism proceeds by first addressing the issue of learners needs and styles. Once these two basic elements have been evaluated, the teacher can develop a needs analysis which can then be used to develop the course syllabus. Definitions Interlanguage Skill: A scala of languages that fit the level of the students language skill at any moment. In other words, there are many levels of speaking a language each of which can be sufficient for a given student.Comprehensible Input: Originated by Krashen, the core of this idea is that if we do not understand the input we cannot learn.Negotiation of Meaning: Interactional hypothesis that states that learning comes about in the moment of exchange between a native speaker and a non-native speaker.Product Oriented Approach: The accumulation of bits and pieces of a language (for example, learning tenses and doing exercises based on correct tense usage). Example Cases The following two cases give examples of the process involved in applying this approach to different types of classes. Class 1 Needs and Styles Age: young adults from 21-30Nationality: class of German students located in GermanyLearning Styles: college educated, familiarity with aà product-oriented approach to learning a language, widely traveled and familiarity with other European cultures.Goals: First Certificate Examination at end of courseInterlanguage Skills: all students can communicate in English and accomplish most common language tasks (i.e., completing day-to-day tasks in a native speaker society, telephone, expressing viewpoints, etc.), higher level complexity such as writing essays, expressing complex arguments in fine detail is next desired step.Course Duration: 100 hours Approach As the First Certificate Examination is the goal of the course and there is a limited number of hours, the course will have to often employ a deductive (i.e., teacher-centered, book learning) approach in order to complete all the grammatical tasks required by the examination.Students are very familiar with traditional learning approaches such as grammar charts, drill exercises, etc. In this case, awareness raising concerning basic language patterns will not be necessary. However, as the students are quite young and most fresh out of college, they may have to be helped to understand and accept more innovative (i.e., inductive) approaches to learning (i.e., role-playing for improving speaking skills, general class discussions with little or no correction) as they are probably used to more goal-oriented study situations.As the First Certificate Exam includes many authentic materials, students will benefit greatly from exercises that focus on the negotiation of meaning. This negotiation of meaning is a type of interactional learning that comes about in the moment of exchange with a native speaker context that requires the learner to negotiate meaning thereby expanding his language skills. Objectives of the First Certificate Examination will be the overriding factor in the determination of class activities. In other words, activities based on Neuro Linguistic Programming may not be desirable as this approach to teaching focuses on a holistic learning method, which, unfortunately, may not provide all the bits and pieces required to complete the examination exercises such as sentence transformation.As the course duration is limited and the objectives are many, there will be little time for experiments and fun activities. Work needs to be focused and principally goal oriented. Class 2 Needs and Styles Age: immigrant adults from 30-65Nationalities: a variety of countriesLearning Styles: most of the class has had little secondary education and has not studied languages formallyGoals: Basic ESL skills for everyday usage and job acquisitionInterlanguage Skills: basic tasks such as ordering a meal and making a telephone call are still difficultCourse Duration: 2-month intensive course meeting four times weekly for two hours Approach The approach to teaching this class is dictated by two principal factors: need for real world skills, lack of background in traditional learning stylesPragmatic functional English is of prime importance. Luckily, the course is intensive and provides the perfect opportunity for intensive role-playing and real world game activities.As students are immigrants and a native speaker environment is at hand, teaching can also take place by bringing the real world into the classroom and/or - even more preferably - taking the classroom out into the real world.Low-level English skills mean that comprehensible input will play a great role in the success or failure of the class. Considering the low level of interlanguage skill, students desperately need the teacher to help them by filtering experiences into a comprehensible form so that they may make sense of situations that are too difficult if faced on a strictly authentic level.Learning by process will be of great importance. The positive side of low-level education is that students are not attached to traditional learning methods such as grammar charts, exercises, etc. The use of holistic learning approaches can be very effective as students will not have any pre-conceived notions about what learning should be like.
Sunday, February 16, 2020
Self-Introductory Speech ( My wedding) Essay Example | Topics and Well Written Essays - 250 words
Self-Introductory Speech ( My wedding) - Essay Example Later in the evening, my female relatives and friends were invited over for dinner during which my husband would see my face for the first time in front of them. The wedding finally took place in the summer on 11th June 2014. We were still in the US at the time, so all the wedding arrangements were made by my family. On the wedding day, Ali went to the barbershop during which he would bond with his male counterparts. There was lunch at the farm for our family and friends as we waited for the actual feast in the evening. In my case, a day prior to the wedding, as Muslim custom dictates, my female friends and high would bond while we put henna on our hands and feet. I woke up very excited on the wedding day, put on my white dress and went to the wedding venue to wait for my husband. The parties were held separately, and I felt overwhelmed with all the love and support I received from my friends and family congratulating me for my wedding and expressing their happiness. Later in the evening, the groomââ¬â¢s party finally joined us, and the festivities continued up to 3 a.m. with people mingling, dancing, taking photos and feasting in the var iety of food. The wedding day is then followed by the Subahia, a small party is held in which the bride and the groom receive gifts from their family, friends and relatives. I believe that my wedding day was one of the most memorable moments in my life, and not just on that particular day but the entire process from the engagement. I hope to base the foundation of my marriage with love and loyalty, and that it always remains one filled with warmth and understanding. Everything turned out to be a success given the support I got from my family and friends on this special
Sunday, February 2, 2020
Theories and Performance Imperatives of Organizational Leadership Research Paper
Theories and Performance Imperatives of Organizational Leadership - Research Paper Example From this research it is clear that effective leaders support the optimal performance of a group of subordinates. They add great value to an organization. Highly effective executives who are also known as peak performers are noted to have productivity rates that are 25 to 50 percent higher than their average or poorly performing counterparts. Highly effective leadership is characterized by productivity, health, relational behaviour, or a combination of these factors, which result in performance at optimal level. The main goals of effective leadership are: facilitating organizational goal setting and helping to achieve them, promoting optimal levels of individual motivation, commitment and satisfaction, facilitating effective interactions among individuals within teams, helping employees to set high goals for themselves, and place the organizationââ¬â¢s effectiveness above their own self-interests. The effective leader operates simultaneously on the performance as well as the peopl e of the organization or unit. Performance includes the process of how things get done, the length of time taken, as well as the outcome of productivity and quality. The aim of performance is productivity, and the aim for people is health. The effective leader operates both requirements successfully, emphasizing both productivity and health. Productivity is the ratio of input to output; and increased productivity has beneficial outcomes such as higher profits and market share. On the other hand, people encompasses the skills, talents, competencies and needs of the employees, leaders and other stakeholders involved with a particular corporation or organization. Health is similar to productivity in being a measure of outcome, and is manifest in both the individual as well as the corporation. For individuals, health includes physical and psychological well-being, job satisfaction, and other factors (Sperry, 2003). Thus, the fundamental premise regarding effective leadership is that it is a function of both productivity and health, and they are inter-connected. By realizing the importance of the people dimension, the effective leader ensures that employeesââ¬â¢ levels of commitment and morale remain high, burnout does not occur, and
Saturday, January 25, 2020
NMDA Receptor Pathways as Drug Targets in CNS Therapeutics
NMDA Receptor Pathways as Drug Targets in CNS Therapeutics 1. Introduction: Glutamate is the king of excitatory neurotransmission in the central nervous system (SNC) and acts on receptors located at the presynaptic terminal and in the postsynaptic membrane at synapses in the brain and spinal cord (Ghasemi and Schachter, 2011). Although glutamate was known to have central nervous system effects for more than 75 years, it was not until 1984 that it was truly acknowledged as fulfilling the criteria of a neurotransmitter. (Niciu et al., 2012). Glutamate receptors are divided into two broad categorizations: ionotropic and metabotropic receptors. Ionotropic glutamate receptors are ion channels that flux cations (Ca2+, Na+) and open the channels in response to agonist binding. On the other hand, metabotropic receptors activate or inhibit second messenger systems via interactions with cognate G-proteins. (Niciu et al., 2012). Ionotropic glutamate receptors can be subdivided into three large families: AMPA receptors (AMPARs), kainate receptors and NMDA receptors (NMD ARs). Since three decades ago, the discovery NMDARs have kept fascinating neuroscientists while their dysfunctions are also involved in various neurological and psychiatric disorders, including stroke, pathological pain, neurodegenerative diseases and schizophrenia. (Paoletti et al., 2013) Fortunately, the NMDA receptor complex is composed with modulatory sites, and the late 1970s and 1980s saw the development of agonists, antagonists and modulators acting at different binding sites. In the last decade, the molecular biology of the NMDA receptors has been defined, and now it is known that these receptors are formed of an NR1 subunit in combination with one or more NR2 or less commonly an NR3 subunit. (Kemp and McKernan, 2002). 2. Molecular mechanisms NMDA receptors are named after their selective agonist N-methyl-D-aspartate. The receptors are multisubunit complexes associating NR1, NR2 and, more rarely, NR3 subunits. NR2 and NR3 subunits exist as four and two subtypes, respectively (NR2A-D and NR3A-B). NR1 exists as seven subtypes (NR1aââ¬âg) (Mony et al., 2009) The receptors are heterotetramers comprising a combination of NR1, NR2A-D andà NR3A-B subunits. The main agonists are glutamate and NMDA, with their binding site on NR2 subunits, while the binding site for the co-agonists D-serine and glycine is located on NR1 and NR3 subunits and the T most common composition of NMDA receptors includes two NR1 and two NR2 subunits, or two NR1, one NR2 and one NR3 subunits (Dzamba et al., 2013). A common structure for glutamate receptors contains an extracellular amino-terminal domain (ATD) for various modulatory functions, extracellular S1S2 domains for agonist binding, an ion channel domain with four transmembrane segments (M1â⠬â4) for gating and ion permeation, and a carboxy-terminal domain for communicating with intracellular milieu Fig 1 (Majdi and Chen, 2009). Pharmacological regulation of the NMDAR depends on effects on unique combinations of subunit-specific binding sites. Once glycine coagonist attaches to its site, the glutamate can activate the ion channel and the Na+ and Ca2+ rush in. The Mg2+ blocks channel pore and the blockade is relieved by cellular depolarization, which has implications for synaptic plasticity, especially long-term potentiation (LTP). (Ghasemi and Schachter, 2011) Most compounds that act at NMDA receptors interact with one of 4 drug binding sites on the NMDA receptor complex, the glutamate or glycine binding sites, the ion channel pore, or a binding site on the regulatory NTD. The first compounds identified were agonists and antagonists of the glutamate like D-à ±-aminoadipic acid and D-2-amino-5phosphonopentanoicà acid (D-AP5) then glycine competitive antagonists like 7-chloro-5-iodokynurenic acid and partial agonists were identified. It was also soon recognized that some dissociative anesthetics (e.g. ketam ine and phencyclidine) were NMDA receptor blockers and the widely used inhibitor MK-801 was shown to be a potent NMDA receptor channel blocker Fig 2 (Monaghan et al., 2012). Another important aspect of NMDA receptor pharmacology is modulation by posttranslational modifications, such as phosphorylation of the intracellular C-terminal of NR2 subunits. NMDA receptor-mediated calcium increases activate many downstream targets like protein kinase C (PKC) and the Modulation by protein kinase C (PKC) depends on NMDA receptor subunit composition; NR2A- and NR2B-containing receptors are potentiated by PKC activation, whereas NR2Cand NR2D containing receptors are unaffected or inhibited by PKC. PKC phosphorylates the NR1 subunit at serine 890 (S890) in the C1 cassette. The potentiatory effects of PKC are not dependent on phosphorylation of NR1, but inhibitory effects are blocked by mutation of S890 or removal of the C1 domain. The NMDA receptor function is also modulated by MAGUK protein fami ly which controls the NMDA receptor localization, the binding to the scaffolding proteins plays a major role in the control of downstream signals resulting from receptor activation. It thought that synaptic NMDA receptors are retained at the synapse by an attachment to PSD-95 through a PDZ interaction with the NR2 subunits.(Gardoni and Di Luca, 2006) 3. Therapeutics A high number of central nervous system disease states in which neuronal cell death is associated to glutamate induced excitotoxicity could be treated by blocking NMDA receptors such as neurological disorders including ischemia, epilepsy, brain trauma, dementia, and neurodegenerative disorders. à ¯Ã¢â¬Å¡Ã · Ischemia : it has been shown that loss of calcium homeostasis may be an important mechanism of ischemic brain damage. Ischemia also resulted in a decrease in the size of protein complexes containing PSD-95. In addition, transient cerebral ischemia increases tyrosine phosphorylation of NMDA receptor subunits NR2A and NR2B. Recent studies suggested to treat stroke transducing neurons with peptides able to disrupt the interaction of NMDA receptor NR2B subunits with the postsynaptic density protein PSD-95. This procedure dissociated NMDA receptors from downstream neurotoxic signaling without blocking synaptic activity or calcium influx and protected cultured neurons from excitotoxi city. .( Gardoni and Di Luca, 2006). Many NR1/NR2B antagonists, including ifenprodil, eliprodil and the selective and potent congeners, Ro 25,6981 and CP-101,606, offer promise in preclinical models of ischaemia (Chazot, 2004) à ¯Ã¢â¬Å¡Ã · Epilepsy: Recent work has suggested that hyper-phosphorylation of NR2B may results in hypersensitivity to the endogenous transmitter, and induction of neuronal hyperexcitability and epilepsy. Furthermore, kainic acid-induced alters tyrosine phosphorylation of NR2A and NR2B receptors. Interestingly, the high affinity NR2B compound, Ro 63-1908 was shown to be active versus acoustic-induced convulsions and NMDA-induced seizures at 4.5 mg/kg ip and 2.31 mg/kg iv, respectively and no adverse cardiovascular, motor deficits or other CNS sideeffects were observed at these active. (Chazot, 2004). à ¯Ã¢â¬Å¡Ã · Huntingtons disease: The normal huntingtin binds to PSD-95 scaffold protein which inhibit the NMDA receptor Overexpression of the normal huntin gtin N terminus significantly attenuates neuronal toxicity induced by both NMDA receptors and the mutated huntingtin. This suggests that PSD-95 is a mediator of neuronal toxicity induced by NMDA receptors and mutated huntingtin. In addition, in a transgenic model of Huntington disease. Other studies show that expression of mutant htt (but not wild-type htt) in combination with NR1/NR2B increases cell death compared toà transfection of only NMDA receptor subunits, suggesting a role for NR1/NR2B NMDA receptors in cell death mediated by mutant htt .As NR2B antagonists block most of the NMDA receptor mediated currents in neuronal models of Huntington, the selective localization of NR2B in the striatum may also play a role in the efficacy of NR2B antagonists against cell death in models of Huntington.( Gardoni and Di Luca, 2006). à ¯Ã¢â¬Å¡Ã · Alzheimers disease : In animal models, NR2B subunit expression decreases with age, which correlates well withreduced Long Term Potentiation (L TP) and inferior cognitive performance. The NR1/NR2B subtype decreases, in comparison to other subtypes, in the frontal cortex of aged humans while overexpression of the forebrain NR2B subunit in transgenic mice has been shown to have profound beneficial effects upon cognitive performance. Such information suggests that controlled potentiation of the NR2B may offer a novel strategy for treating cognitive disabilities. (Chazot, 2004). à ¯Ã¢â¬Å¡Ã · Parkinsons disease: At the molecular level, alterations of NMDA receptor subunits localization in striatum have been described in Dopamine-denervated rats as well as in L-DOPA-treated dyskinetic monkeys. In particular, NR2B subcellular redistribution from synaptic to extrasynaptic sites represents the key element in the complex modifications of the glutamatergic synapse in L-DOPA-induced dyskinesia. On the other hand, recent studies in primates suggested that upregulation of NR2A abundance in synaptosomal membranesmay be an important pla yer in L-DOPA induced dyskinesias. And recently, two studies described results on the effects of NR2B selective NMDA receptor antagonist CP-101,606 on L-DOPA induced dyskinesia in two different models of experimental parkinsonism.( Gardoni and Di Luca, 2006). à ¯Ã¢â¬Å¡Ã · Psychosis : Studies have suggested that the NR2B has role in psychotic disorders, including schizophrenia and bipolar disorder. The mRNA encoding the NR2B subunit and NR1/NR2B-type binding sites have been shown to be selectively increased in hippocampal and cortical regions, Recent work has identified a novel T200G variant located in the NR2B promoter, which endows dysfunction of the NR2B subunit. The frequency of this variant was significantly up-regulated in a schizophrenia group compared to a control group. The possible link between these observations is yet to be investigated. (Chazot, 2004). à ¯Ã¢â¬Å¡Ã · Pain: Studies suggest that the NR2B subunit plays distinct roles in acute and chronic pain states, re cently NR2B antagonists were developped, including Ro 25,6981, CP -101,606, PD 174494 and PD 196860, are effective in a range of animal chronic pain models with a wide separation between anti-hyperalgesic and side-effect doses . . (Chazot, 2004). 4. References Chazot, P. L. (2004). The NMDA receptor NR2B subunit: A valid therapeutic target forà multiple CNS pathologies. Curr. Med. Chem. 11, 389-396. Dzamba, D., Honsa, P. and Anderova, M. (2013). NMDA receptors in glial cells: Pendingà questions. Current Neuropharmacology 11, 250-262. Gardoni, F. and Di Luca, M. (2006). New targets for pharmacological intervention in theà glutamatergic synapse. Eur. J. Pharmacol. 545, 2-10. Ghasemi, M. and Schachter, S. C. (2011). The NMDA receptor complex as a therapeuticà target in epilepsy: A review. Epilepsy Behavior 22, 617-640. Kemp, J. A. and McKernan, R. M. (2002). NMDA receptor pathways as drug targets. Nat.à Neurosci. 5, 1039-1042. Majdi, M. and Chen, H. V. (2009). NMDA-gated ion channel research and its therapeuticà potentials in neurodegenerative diseases: A review. Journal of Receptor, Ligand and Channel Research 2, 59-73. Monaghan, D. T., Irvine, M. W., Costa, B. M., Fang, G. and Jane, D. E. (2012).à Pharmacological modulation of NMDA receptor activity and the advent of negative andà positive allosteric modulators. Neurochem. Int. 61, 581-592. Mony, L., Kew, J. N., Gunthorpe, M. J. and Paoletti, P. (2009). Allosteric modulators ofà NR2Bà ¢Ã¢â ¬Ã containing NMDA receptors: Molecular mechanisms and therapeutic potential. Br. J.à Pharmacol. 157, 1301-1317 Niciu, M. J., Kelmendi, B. and Sanacora, G. (2012). Overview of glutamatergicà neurotransmission in the nervous system. Pharmacology Biochemistry and Behavior 100,à 656-664. Paoletti, P., Bellone, C. and Zhou, Q. (2013). NMDA receptor subunit diversity: Impact onà receptor properties, synaptic plasticity and disease. Nature Reviews Neuroscience 14, 383-400.
Friday, January 17, 2020
Economics at the University of Pennsylvania Essay
Although I want to major in Economics at the University of Pennsylvania, I have a passion for poetry and prose, and I would love more than anything to develop my writing skills in Pennââ¬â¢s School of Arts and Sciences. That program provides the disciplined and distinguished qualities that I seek. One must be a great reader before becoming a great writer, so I indulge in books of every genre to expand my range of knowledge. Literature brings me great joy, and I will strive to integrate my fondness for reading and writing into my college experience. Pennââ¬â¢s English Department is unique in that it provides the opportunity for students to place an emphasis on studies in creative writing. Within that framework, I want to channel my passion for poetry into academia. As founder and president of Shandong Normal University Literature Association, if accepted, I plan to visit the Kelly Writers House religiously as a way to satisfy my perpetual craving for remarkable literature. I envision myself grabbing a turkey and cheese sandwich with no mayonnaise at the 1920 Commons, then rushing off to the Kelly Writers House with an armful of books by Maya Angelou and Eric Schlosser. Gathered in a tight circle of chairs, I want to share professional works with fellow literature lovers. We will offer our own daring lines of free verse, swap suggestions, compliments, and light-hearted laughs. During workshops, my very soul seeps steadily through an invisible tube from brain to ballpoint. This complex phenomenon of input-output produces painstakingly arranged ink on paper, a painting made of letters. On my way to a morning class on modern American poetry, I will pass Oldenbergââ¬â¢s famed Split Button and acknowledge Mr. Franklin sitting upright in his chair. After the lecture, I can envision Professor Josephine Park and I conducting research by analyzing the influence of conflicts between America and East Asia on Asian-American texts. As part of the Penn family, I will converse with colleagues, sisters, and brothers that destiny forgot to recognize. Then, I will tutor secondary school students about reading and writing through the outreach program. Having been featured in a myriad of written works and publishing my own collections, I will roll up my sleeves and organize literary pieces in the weekly undergraduate magazine, First Call. As evening emerges, I will bike to the Van Pelt Library, work comfortably in my favorite armchair, and complete the finishing touches on a Second World War paper. Traveling to other parts of the City of Brotherly Love, study group friends and I will order a few Philly Cheesesteaks from Patââ¬â¢s King of Steaks for dinner. My roommate, with lips coated in frothy toothpaste, will open the door when I get back. After taking a shower, I will dry my hair on a blue polka dot towel, sit on my bed, and chortle cheerfully while my roommate chatters about the highlights of her day. Then I will read an article about the Penn Museum from The Daily Pennsylvanian. After turning off the lights and setting my alarm clock for 6:00am, I will drape my jogging shorts and shirt on a chair for the morning. Before drifting off to sleep, I will fondly recall submitting my application to Penn, and smile in the quiet of my room, happy to be here at last.
Thursday, January 9, 2020
The Picture Of Dorian Gray - 1680 Words
At the height of his success, Oscar Wilde wrote his novel The Picture of Dorian Gray, which follows the life of a young man living in late nineteenth-century London. The novel shares a similar storyline with that of Wildeââ¬â¢s life, as Wilde wrote it in attempt to justify his homosexuality. The protagonist of the novel, Dorian Gray, enters the story an innocent man, but eventually becomes corrupt due to his need for instant pleasure. Wilde recognizes that the topic of his homosexuality brings up the importance of challenging society, but he uses Dorianââ¬â¢s character to depict the dangers of completely disobeying society. He does so by making Dorian succumb to the temptations of hedonism, the pursuit of instant pleasure through any means possible, in this novel. Wilde faced persecution by society, and hoped that through his novel he could show society the truly corrupt actions of people, therefore proving that his homosexuality does not compare to morally wrong actions like m urder. Wilde wanted society to understand that lifeââ¬â¢s meaning involves living with some rejection to societal acceptance and morals, and that people should find a stable balance between the rights and wrongs of society and live upon that as he did. After having married and raising two children, Oscar Wilde discovered his homosexuality upon meeting John Gray in 1889. Perhaps because John felt indifferent towards Wilde, Wilde launched a campaign to win Johnââ¬â¢s affection. The resulting relationship became theShow MoreRelatedThe Picture Of Dorian Gray1482 Words à |à 6 Pagesreturn give to the same storyâ⬠(Foster 185-186). One book that is a part of Fosterââ¬â¢s story is Oscar Wildeââ¬â¢s The Picture of Dorian Gray. In this essay, Thomas Fosterââ¬â¢s methods regarding both symbolism and à ¬Ã ¬Ã ¬Ã ¬heart disease from his book, How to Read Literature Like a Professor will be discussed and applied to one of Oscar Wildeââ¬â¢s novels. Throughout his nove l, The Picture of Dorian Gray, Oscar Wilde uses the portrait of the young protagonist as a symbol of many things, one of them being a mirror. WildeRead MoreThe Picture Of Dorian Gray Essay1460 Words à |à 6 PagesAs seems to be the theme of Oscar Wildeââ¬â¢s book, The picture of Dorian Gray, art an beauty are both the same, yet they are different. But how can this be? Well, beauty and art are intertwined the moment art is used to capture a sliver of pure beauty, in order to make that moment last forever. According to Lord Henry, ââ¬Å" Yes, Mr. Gray, the gods have been good to you. But what the goods give can easily be taken away. You only have a few years in which to live really, perfectly, and fullyâ⬠(Wilde Pg.Read MoreThe Picture Of Dorian Gray1432 Words à |à 6 PagesIn The Picture of Dorian Gray by Oscar Wilde, we see how the different characters show their love of beauty and pleasure and the affects they have on the main character: Dorian Gray. Each of the three main characters, Basil Hallward, Lord Henry Wotton, and Dorian Gray portray a part of how the author felt about himself and the world around him. ââ¬Å"Basil Hallward is what I think I am: Lord Henry what the world thinks of me: Dorian what I would like to be- in other ages, perhapsâ⬠(qtd. in Bloom pg. 117)Read MoreThe Picture Of Dorian Gray1576 Words à |à 7 PagesTransformation in Literature Greek Philosopher Heraclitus once said ââ¬Å"There is nothing permanent except changeâ⬠. In Oscar Wildeââ¬â¢s The Picture of Dorian Gray, the theme of transformation is constant throughout the novel; however it is not portrayed as something that is permanent. Through the protagonistââ¬â¢s transformation, Oscar Wilde s novel is suggesting that the hedonistic lifestyle, a lifestyle where gaining pleasure is the main goal of a personââ¬â¢s life, may seem like it is an exciting and wonderfulRead MoreThe Picture Of Dorian Gray965 Words à |à 4 Pages When looking at Frankenstein and The Picture of Dorian Gray, it is clear that Frankenstein is a novel that can be placed into both the gothic and horror genre, although it is a gothic novel secondary to it being a horror novel; The picture of Dorian Gray isnââ¬â¢t so clear in this regard. On a first reading, one may assume the story to be gothic literature and only gothic literature because of the sheer amount of gothic characteristics and elements that the text presents that include, but are not limitedRead MoreThe Picture Of Dorian Gray957 Words à |à 4 PagesWilde explores the theme of outsiders in his 1890 novel, The Picture of Dorian Gray. He infuses what it means to be an outsider in almost every character in the story. The most important of these characters are Dorian Gray, Henry, and Basil. Each show what it means to be an outsider in his own individual way; whether it is an outsider among society, among a group of friends, or from a personââ¬â¢s own self. The main character, Dorian Gray, possesses most attributes of being an outsider. The most obviousRead MoreThe Picture Of Dorian Gray971 Words à |à 4 PagesIn Oscar Wildeââ¬â¢s Popular nineteenth century novel, the Picture of Dorian Gray demonstrates the importance of the aesthetic movement in Victorian England. This suggests youth and physical attractiveness is emphasized and are valuable additions to society. Therefore, what matters to Dorian, is not the internal goodness an individual possesses but the appearance they present. Consequently, Dorian is able to forget the violent acts he commits as long as he appears beautiful on the outside. Since externalRead MoreThe Picture Of Dorian Gray1211 Words à |à 5 PagesIn The Picture of Dorian Gray, Oscar Wilde warns against immorality, vanity and selfishness using his protagonistââ¬â¢s downfall to show the dangers of overindulgence and depravity. The preface is contradictory and reveals that Wildeââ¬â¢s beliefs on art and its ties to morality were inconsistent. He appears to be trying to show that we shouldnââ¬â¢t subscribe to just one clear ideal without questioning it or considering other opinions. However, itââ¬â¢s clear throughout the book that there is a strong moral ideologyRead MoreThe Picture Of Dorian Gray1283 Words à |à 6 PagesWhat does the fall of man, Oscar Wilde novel The Picture Of Dorian Gray, and Shakespeareââ¬â¢s Macbeth all have in common? They all have the same theme of the fall of man and break in the perfect union they once where in. The novels all start with man in perfect union, then sin enters and chaos starts and it eventually leading to their death or downfall. The Fall of man, Shakespeareââ¬â¢s Macbeth and Wildeââ¬â¢s novel The Picture Of Dorian Gray tightly follow the archetype of the fall of man this is all illustratedRead MoreThe Picture Of Dorian Gray864 Words à |à 4 PagesWhile God in America: A New Adam illustrates the positive effects influence has on an individual, The Picture of Dorian Gray by Oscar Wilde exhibits the negative consequences influence has on an individual who conforms to societyââ¬â¢s beliefs. Compared to the Spanish, the Puritans succeeded in the teachings of their religion because they endorsed individual thought rather than collective thoughts. Upon their arrival to New Mexico, the Spaniard missionaries believed it was their mission from God to ââ¬Å"save
Wednesday, January 1, 2020
Approaching Questions beyond Science Philosophy vs Religion - Free Essay Example
Sample details Pages: 4 Words: 1236 Downloads: 8 Date added: 2019/03/11 Category Religion Essay Level High school Tags: Science vs Religion Essay Did you like this example? Dreadââ¬âthe driving force of some of the greatest minds to find answers to lifeââ¬â¢s biggest questions. An equally perplexing challenge is how to begin tackling such problems. By focusing on one dilemma and comparing how both schools of thought attempt to solve the problem, a hint may be revealed as to which approach to prefer. Philosophy is based on open discussion and human reasoning, as a result it is better suited than religion to explore what is beyond scienceââ¬âthe meaning of life. Within themselves, philosophy and religion do not produce a satisfactory answer because of disagreement. Two well known philosophers such as Friedrich Nietzsche and Aristotle give starkly contrasting answers to life. Nietzsche argues in his book ââ¬Å"The Birth of Tragedyâ⬠that there is no inherent meaning in life at all, instead it is art that gives it meaning (p. 52). While, Aristotle would say that happiness is a central purpose of human life (pp. 2). Religion disagrees within itself just as much evidently. Each spirituality has its own entirely different doctrine. Disagreement is at the core of this search for ââ¬Å"The Answerâ⬠. Through open discussion, this becomes a weakness for religion but a strength for philosophy. Donââ¬â¢t waste time! Our writers will create an original "Approaching Questions beyond Science Philosophy vs Religion" essay for you Create order The principle of symposium within religion was terminated when each religious historical figure claims his doctrine as the ultimate truth. Jesus Christ establishes Heaven and Hell as the afterlife in Christianity. Siddhartha Gautama, founder of Buddhism, proposes a path to enlightenment to go beyond life and pain. This list of differing teachings can go on indefinitely. The crux of disagreeing beliefs among religions is that it is treated as a dividing force. Any disagreement is enough grounds to simply separate oneself from a denomination and start their own. Albeit the controversy was not on the meaning of life, the most famous example of this was when Martin Luther started a cascade of dividing denominations with his 95 theses. Disagreement was present in the Catholic Church, their solutionââ¬âdivision. Although relatively harmless when compared to religious crusades, the division of religion has only made the search for a single agreeable teaching even murkier because the amo unt of doctrines claiming to be the ultimate truth multiplies. In religion, disagreement is a drawback because not only does it cause separation, it is counterproductive against humanityââ¬â¢s attempt at finding a solution. On the contrary, in philosophy, disagreement and discussion is at the heart of finding certain truths. Theorist Edmund Burke, in his dissertation ââ¬Å"Of the Standard of Tasteâ⬠, he demonstrates how two wine critics with differing critiques were partially wrong alone, but correct together. At a wine test, one critic tasted leather and another tasted iron while unknown to them there was a key on a leather strap at the bottom of the barrel. Both initially disagreed, but through open discussion, synthesized their findings and resulted in a true critique. This concept is not only limited to artistic taste, it is prevalent in all of philosophy. In other words, approaching ââ¬Å"The Big Questionâ⬠with open discussion and proactive synthesis aims humanityââ¬â¢s attempts in the correct direction. Moving on from how both schools of thought handle disagreement and approach an answer, one must step back and consider what their views are based on after all. In the school of philosophy, theories are based on human reason, rationality and logic. Although not all religious beliefs are this way, most divine beliefs are based on pure faith. If enough steps are retraced, then it becomes evident that an assumption is at the root of any theory deduced thereof. It does not necessarily immediately discount its validity or mean that they are not true. Such theories are to be taken with a grain of salt because of its inherent uncertainty. The advantage in philosophy is that it isnââ¬â¢t held back by uncertainty. Although religious beliefs on how to live life are hardly disputed, its claims on a higher power are based on an unverifiable argument and are indeed heavily disputed among religion. In Christianity, an elaborate and elegant afterlife is depicted, and Jesus is the guide to said afterlife. These claims are true, if Jesus without a doubt is indeed The Son of a Higher Power. The inability to neither prove or disprove Jesusââ¬â¢s divine affiliation, makes it a postulate at bestââ¬âan assumption. This axiom ,based on pure faith, gives birth to Christianity and makes all theories of the divine derived from Jesus true. Islamââ¬â¢s axiom is Muhammadââ¬â¢s legitimacy as Allahââ¬â¢s prophet. Making a decision, or believing something to be true because of faith is, effectively a low risk gamble. Religion approaches the meaning of life by effectively gambling on an axiom, complicating the validity of i ts claims and falling on the wrong side of Occamââ¬â¢s razor, an english philosopherââ¬â¢s greatest contribution to human reasoning . In philosophy, it is Occamââ¬â¢s Razor that declutters the sea of countless theories on the meaning of life. His razor is a principle that states the explanation that makes the least assumptions should be prefered. Occamââ¬â¢s razor does not confirm the validity of a theory, instead it merely serves a guide as to which theory to employ. What heavily differentiates philosophy from religion is that, assumptions are hardly used, if not entirely avoided. The basis for a theory on philosophy is usually deduced logically from given information rather than postulated. After observing the similarities between the real world and art, Plato deduced that Art imitates life. In a modern world context, neuroscientist/philosopher Guillaume Thierry conducted an 18 year study on the brain and concluded that the meaning of life lies in our brains ability to deduce meaning at all (pp. 2). The key point from this is that philosophers observed the subject matter first then through human reasoning a nd logic, deduced a verifiable argument backed by empirical evidence. In other words, assumptions were avoided. Occamââ¬â¢s razor states that the simplest theories with the least assumptions should be sought first. Philosophy approaches the meaning of life through basing its theories on verifiable arguments, empowering its certainty and earning priority consideration in the search for an ââ¬Å"answerâ⬠. Alas, philosophy is not perfect. Human reason is the pillar of philosophical thought, but it may just also be its crux. Since human reason is secular, it may only exist and operate within the secular realmââ¬âit is incapable of coming to a supernatural conclusion without making the leap of faith. Religionââ¬â¢s only advantage over philosophy is its ability to consider and theorize the celestial. Because the spiritual can neither be confirmed nor denied, this advantage is neutralized. In other words, philosophyââ¬â¢s limit is the heavenly realm, but because the divine realm cannot be confirmed the religious realm is no greater but no less than the known secular realm. Figuring out how to answer the meaning of life is just as daunting as the question itself. Religion approaches it by basing its theories on axioms. On the other hand, philosophy deduces principles through observation and reasoning. It also improves its current theories through finding common grounds among disagreement as an indication of a certain truth. Religionââ¬â¢s ability to consider the divine proves itself to be no less but no greater than secular reasoning. Considering Occamââ¬â¢s razor, overall certainty, and its principle of open discussion, philosophy is indeed the school of thought better suited to explore what is beyond our observable life.
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